DUSP26

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Description

The DUSP26 (dual specificity phosphatase 26) is a protein-coding gene located on chromosome 8.

DUSP26 inactivates MAPK1 and MAPK3, leading to dephosphorylation of heat shock factor protein 4 and reduced DNA-binding activity. It also inhibits MAP kinase p38 by dephosphorylation, preventing p38-mediated apoptosis in anaplastic thyroid cancer cells. Interestingly, DUSP26 can also activate MAP kinase p38 and c-Jun N-terminal kinase (JNK).

DUSP26 is also known as DSP-4, DUSP24, LDP-4, LDP4, MKP-8, MKP8, NATA1, NEAP, SKRP3.

Associated Diseases

• hemoglobin E-beta-thalassemia syndrome
• dehydrated hereditary stomatocytosis
• cholesterol-ester transfer protein deficiency
• hypertriglyceridemia 2
• gluthathione peroxidase deficiency
• sitosterolemia
• hemolytic anemia due to erythrocyte adenosine deaminase overproduction
• IRIDA syndrome
• hemochromatosis type 5
• microcytic anemia with liver iron overload
• Rh deficiency syndrome
• pancreatic triacylglycerol lipase deficiency