DUSP2

Description

The DUSP2 (dual specificity phosphatase 2) is a protein-coding gene located on chromosome 2.

Dual specificity protein phosphatase 2 is an enzyme encoded by the DUSP2 gene in humans. It belongs to the dual specificity protein phosphatase subfamily, which inactivate target kinases by dephosphorylating both phosphoserine/threonine and phosphotyrosine residues. These phosphatases negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), involved in cellular proliferation and differentiation. Different members of the dual specificity phosphatase family exhibit distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. The DUSP2 gene product inactivates ERK1 and ERK2, is mainly expressed in hematopoietic tissues, and is localized in the nucleus.

Dephosphorylates both phosphorylated Thr and Tyr residues in MAPK1, with a slightly faster dephosphorylation rate for phosphotyrosine compared to phosphothreonine (PubMed:8107850). Also capable of dephosphorylating MAPK1 (By similarity). {ECO:0000250|UniProtKB:Q05922, ECO:0000269|PubMed:8107850}

DUSP2 is also known as PAC-1, PAC1.

Associated Diseases

WES Whole Exome Sequencing