DUSP13
DUSP13: A Versatile Regulator in Human Health and Disease
Introduction
Dual-specificity phosphatase 13 (DUSP13) is a crucial regulator in various cellular processes, impacting human health and disease. Its diverse roles range from immune modulation to cognitive function.
Description of DUSP13
DUSP13 belongs to the mitogen-activated protein kinase (MAPK) phosphatase family. It specifically dephosphorylates and inactivates MAPKs, primarily p38 and JNK, which are central players in stress responses, inflammation, and cell fate decisions.
Associated Diseases
Dysregulation of DUSP13 has been linked to numerous human diseases, including:
- Inflammatory conditions: DUSP13 deficiency exacerbates inflammation in diseases such as sepsis, rheumatoid arthritis, and inflammatory bowel disease.
- Neurological disorders: Mutations in DUSP13 have been associated with intellectual disability, autism spectrum disorder, and schizophrenia.
- Cardiovascular diseases: Reduced DUSP13 expression is implicated in cardiac hypertrophy and heart failure.
- Cancer: Deregulated DUSP13 can promote tumor growth and metastasis in certain types of cancer.
Did you Know ?
Approximately 20% of individuals with a diagnosis of idiopathic intellectual disability have mutations or deletions in the DUSP13 gene.
