DUSP12
Description
The DUSP12 (dual specificity phosphatase 12) is a protein-coding gene located on chromosome 1.
DUSP12 is a human gene that encodes the enzyme dual specificity protein phosphatase 12. This enzyme belongs to a family of phosphatases that inactivate target kinases by removing phosphate groups from both phosphoserine/threonine and phosphotyrosine residues. These phosphatases play a regulatory role in the mitogen-activated protein (MAP) kinase superfamily, which is involved in cellular processes like proliferation and differentiation. DUSP12, specifically, is the human counterpart of the YVH1 protein tyrosine phosphatase found in Saccharomyces cerevisiae. It is primarily localized in the nucleus and is distinguished by its zinc finger domain, which regulates its activity.
DUSP12 is a dual specificity phosphatase that can remove phosphate groups from both phosphotyrosine and phosphoserine or phosphothreonine residues. It has been shown to dephosphorylate glucokinase in vitro. Additionally, DUSP12 exhibits phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate and other in vitro substrates. These activities have been experimentally demonstrated (UniProtKB:Q9JIM4, PubMed:10446167, PubMed:24531476).
DUSP12 is also known as DUSP1, YVH1.
Associated Diseases
- pigmented nodular adrenocortical disease, primary, 3
- congenital adrenal hyperplasia due to cytochrome P450 oxidoreductase deficiency
