DUSP10
Description
The DUSP10 (dual specificity phosphatase 10) is a protein-coding gene located on chromosome 1.
DUSP10 is an enzyme encoded by the human DUSP10 gene. It belongs to the family of dual specificity protein phosphatases, which inactivate kinases by removing phosphate groups from both serine/threonine and tyrosine residues. DUSP10 specifically regulates the MAPK superfamily, which plays a role in cell growth and differentiation. It inactivates p38 and SAPK/JNK, but not MAPK/ERK. DUSP10 is unique in its distribution, being found equally in both the cytoplasm and nucleus. Its expression is widespread across tissues and organs and is increased by stress. Three different transcripts encoding two isoforms have been identified for this gene. DUSP10 has been shown to interact with MAPK14 and MAPK8.
DUSP10 is also known as MKP-5, MKP5.
