DTNB
Description
The DTNB (dystrobrevin beta) is a protein-coding gene located on chromosome 2.
Dystrobrevin beta is a protein encoded by the DTNB gene in humans. It is a component of the dystrophin-associated protein complex (DPC), which also includes dystrophin and other integral and peripheral membrane proteins like dystroglycans, sarcoglycans, syntrophins, and dystrobrevin alpha. The DPC localizes to the sarcolemma, and its disruption is linked to various forms of muscular dystrophy. Dystrobrevin beta is believed to interact with syntrophin and the DP71 short form of dystrophin. Different isoforms are produced due to alternative splicing of the DTNB gene.
DTNB, also known as dystrobrevin beta, plays a crucial role in assembling DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids. It may act as a repressor of the SYN1 promoter by binding to repressor element-1 (RE-1), thereby regulating SYN1 expression and potentially influencing cell proliferation during early neural differentiation. Additionally, DTNB might be essential for the proper maturation and function of a specific group of inhibitory synapses.
DTNB is also known as -.
