DTNA
Description
The DTNA (dystrobrevin alpha) is a protein-coding gene located on chromosome 18.
Dystrobrevin alpha is a protein encoded by the DTNA gene in humans. It is part of the dystrobrevin subfamily and the dystrophin family, and is a component of the dystrophin-associated protein complex (DPC). The DPC, which includes dystrophin and various membrane proteins like dystroglycans, sarcoglycans, syntrophins, and alpha- and beta-dystrobrevin, is located at the sarcolemma. Disruptions in the DPC are linked to different forms of muscular dystrophy. DTNA may play a role in synapse formation and stability, as well as the clustering of nicotinic acetylcholine receptors. Multiple transcript variants encoding various isoforms have been identified. Mutations in DTNA are associated with Ménière's disease. Dystrobrevin has been shown to interact with dystrophin.
DTNA is believed to play a role in synapse formation and stability, as well as in the aggregation of nicotinic acetylcholine receptors.
DTNA is also known as D18S892E, DRP3, DTN, DTN-A, LVNC1.
