DSPP : dentin sialophosphoprotein
Description
The DSPP (dentin sialophosphoprotein) is a protein-coding gene located on chromosome 4.
The DSPP gene provides instructions for making dentin sialophosphoprotein, a protein that is cut into two smaller proteins: dentin sialoprotein and dentin phosphoprotein. These proteins are essential components of dentin, the hard middle layer of teeth. Dentin phosphoprotein is thought to be involved in the hardening of collagen, the primary protein in dentin, by helping to deposit mineral crystals among collagen fibers. While the exact functions of the DSPP-derived proteins are unknown, they are crucial for normal tooth development. The DSPP gene is also active in the inner ear, but its role in hearing is unclear.
DSPP is also known as DFNA39, DGI1, DMP3, DPP, DSP.
Associated Diseases
- Dentinogenesis imperfecta, shields type III
- Deafness, autosomal dominant 39, with dentinogenesis imperfecta 1
- Dentin dysplasia, type II
- Dentinogenesis imperfecta 1
- Nonsyndromic hearing loss
- Dentinogenesis imperfecta
