DRD4
Description
The DRD4 (dopamine receptor D4) is a protein-coding gene located on chromosome 11.
The dopamine receptor D4, encoded by the DRD4 gene, is a G protein-coupled receptor that belongs to the D2-like dopamine receptor family. It is located on chromosome 11 at position 11p15.5 and is known to be involved in a range of neurological and psychiatric conditions, including schizophrenia, bipolar disorder, ADHD, addiction, Parkinson's disease, and eating disorders. The receptor is activated by dopamine and plays a role in regulating emotions and behaviors. The DRD4 gene has several variations, including a 48-base pair VNTR in exon 3, which has been linked to differences in dopamine potency and behavioral traits. The D4 receptor is targeted by drugs used to treat schizophrenia and Parkinson's disease.
The DRD4 gene encodes the dopamine receptor D4, a G protein-coupled receptor involved in neuronal signaling within the mesolimbic system of the brain. This system regulates emotions and complex behaviors. The receptor is activated by dopamine, but also responds to epinephrine, norepinephrine, and various synthetic agonists and drugs. Agonist binding initiates signaling through G proteins, which ultimately inhibit adenylyl cyclase. DRD4 plays a role in modulating the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in retinal ganglion cells. The receptor can form homo- and heterooligomers with DRD2, with variations in affinity based on the specific alleles. Interactions with other proteins, including CLIC6, GPRASP1, ADORA2A, and KLHL12, are also reported.
DRD4 is also known as D4DR.
