DRD1

Description

The DRD1 (dopamine receptor D1) is a protein-coding gene located on chromosome 5.

DRD1, also known as Dopamine receptor D1, is a protein encoded by the DRD1 gene. It's one of the two types of D1-like receptor family, along with D5. DRD1 is most abundant in the central nervous system, particularly in the dorsal striatum (caudate and putamen) and ventral striatum (nucleus accumbens and olfactory tubercle). Lower levels are found in the basolateral amygdala, cerebral cortex, septum, thalamus, and hypothalamus. DRD1 plays a crucial role in memory, learning, and neuronal growth. It's also involved in the reward system and locomotor activity, mediating certain behaviors and modulating the effects of dopamine receptor D2. DRD1 contributes to addiction by facilitating gene expression changes in the nucleus accumbens during addiction. It is coupled to Gs and can stimulate neurons by activating cyclic AMP-dependent protein kinase. The DRD1 gene primarily expresses in the caudate putamen in humans and the caudate putamen, nucleus accumbens, and olfactory tubercle in mice.

DRD1 is also known as D1R, DADR, DRD1A.

Associated Diseases

• Parkinson disease
• schizophrenia
• multiple sclerosis
• Alzheimer disease
• lysosomal storage disease
• depressive disorder
• refractive error