DRAXIN
Description
The DRAXIN (dorsal inhibitory axon guidance protein) is a protein-coding gene located on chromosome 1.
Draxin is a chemorepulsive axon guidance protein crucial for the proper development of the spinal cord and forebrain commissures. During development, it acts as a guidance cue that directs commissural axons to their destinations. Draxin exerts its influence by repelling neurite outgrowth from the dorsal spinal cord. Furthermore, it interacts with the LRP6 protein, inhibiting the stabilization of beta-catenin (CTNNB1), thereby acting as an antagonist of the Wnt signaling pathway.
DRAXIN is also known as AGPA3119, C1orf187, UNQ3119, neucrin.
Associated Diseases
- schizencephaly
- mirror movements 1
- hyperinsulinism due to INSR deficiency
- microcephaly-polymicrogyria-corpus callosum agenesis syndrome
- polymicrogyria with optic nerve hypoplasia
- autosomal recessive primary microcephaly
- complex cortical dysplasia with other brain malformations 7
- hyperinsulinism due to glucokinase deficiency
- exercise-induced hyperinsulinism
- pyruvate dehydrogenase E1-beta deficiency
- sub-cortical nodular heterotopia
- Chudley-McCullough syndrome
- lissencephaly 4
- lissencephaly due to TUBA1A mutation
- ventriculomegaly and arthrogryposis
- familial congenital mirror movements
- craniotelencephalic dysplasia
- autosomal recessive spastic paraplegia type 69
