DPY30
Description
The DPY30 (dpy-30 histone methyltransferase complex regulatory subunit) is a protein-coding gene located on chromosome 2.
DPY30 is part of the MLL1/MLL complex, which is involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. This methylation marks the gene for epigenetic transcriptional activation. DPY30 may also play a role in histone H3 acetylation. In a teratocarcinoma cell, DPY30 is crucial for retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. DPY30 may also play a role in endosomal transport.
DPY30 is also known as Cps25, HDPY-30, Saf19.
Associated Diseases
- hereditary spastic paraplegia 4
- alopecia
- isolated hyperchlorhidrosis
- hearing loss-familial salivary gland insensitivity to aldosterone syndrome
- cancer
- hereditary spastic paraplegia
- glioblastoma
