DOCK10
Description
The DOCK10 (dedicator of cytokinesis 10) is a protein-coding gene located on chromosome 2.
DOCK10, also known as Zizimin3, is a large protein (~240 kDa) involved in intracellular signaling networks. It belongs to the DOCK-D subfamily of the DOCK family of guanine nucleotide exchange factors, which function as activators of small G-proteins. DOCK10 was identified through bioinformatic analysis as part of a family of evolutionarily conserved proteins. It is expressed in various tissues, including peripheral blood leukocytes, brain, spleen, lung, and thymus. DOCK10 shares structural features with other members of the DOCK-D/Zizimin subfamily, including a DHR2 domain involved in G protein binding, a DHR1 domain that interacts with membrane phospholipids, and an N-terminal PH domain. The DHR2 domain of DOCK10 binds to the small G proteins Cdc42, TC10, and TCL, although these interactions are of low affinity. The precise physiological role of DOCK10 is not fully understood, but studies have shown that its expression is upregulated in B-lymphocytes and Chronic Lymphocytic Leukemia (CLL) cells in response to the cytokine IL-4, suggesting a potential role in B-cell activation and proliferation.
DOCK10 is also known as DRIP2, Nbla10300, ZIZ3.
