DOC2B
Description
The DOC2B (double C2 domain beta) is a protein-coding gene located on chromosome 17.
DOC2B is a protein encoded by the DOC2B gene in humans. There are two isoforms, alpha (DOC2A) and beta (DOC2B), each containing two C2-like domains. While DOC2A and DOC2B are encoded by separate genes, they are sometimes confused with the unrelated DAB2 gene, which was initially called DOC-2. DOC2B enhances calcium-dependent exocytosis in adipocytes, chromaffin cells, and pancreatic beta cells. In the central nervous system, DOC2B contributes to the spontaneous release of neurotransmitters. Initially, it was believed that DOC2B acted as a high-affinity calcium sensor for synaptic vesicle exocytosis. However, further research has shown that while DOC2B is essential for spontaneous exocytosis and binds calcium, it does not alter the calcium dependence of this process, suggesting that it is not the primary calcium sensor.
DOC2B is also known as DOC2BL.
