DNTT

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Description

The DNTT (DNA nucleotidylexotransferase) is a protein-coding gene located on chromosome 10.

DNTT is a template-independent DNA polymerase that adds deoxynucleoside 5'-triphosphate randomly to the 3'-end of DNA. It plays a critical role in the immune system, specifically in the maturation of B and T cells by adding nucleotides at the junction (N region) of rearranged immunoglobulin heavy chain and T-cell receptor gene segments.

DNTT is also known as TDT.

Associated Diseases

• Okt4 epitope deficiency
• hypertriglyceridemia 2
• cholesterol-ester transfer protein deficiency
• transient myeloproliferative syndrome
• combined immunodeficiency with skin granulomas
• classic Hodgkin lymphoma
• 22q11.2 deletion syndrome
• thyroid hormone metabolism, abnormal, 2
• sitosterolemia
• seminoma
• homozygous familial hypercholesterolemia
• immunodeficiency 19
• T-cell immunodeficiency, congenital alopecia, and nail dystrophy