DNAJC7

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Description

The DNAJC7 (DnaJ heat shock protein family (Hsp40) member C7) is a protein-coding gene located on chromosome 17.

DnaJ homolog subfamily C member 7 is a protein that in humans is encoded by the DNAJC7 gene.

DNAJC7 acts as a co-chaperone, regulating the folding of steroid receptors like the glucocorticoid and progesterone receptors by interacting with the molecular chaperones HSP70 and HSP90. It is proposed to act as a recycling chaperone, facilitating the return of substrates to earlier stages of chaperoning if further folding is required. In laboratory settings, DNAJC7 can detach HSP90 from chaperone-substrate complexes without needing ATP, but it does not detach HSP70. DNAJC7 can move NR1I3 to the cytoplasm.

DNAJC7 is also known as DJ11, DJC7, TPR2, TTC2.

Associated Diseases

• amyotrophic lateral sclerosis
• low grade glioma
• hereditary persistence of fetal hemoglobin-sickle cell disease syndrome
• hemoglobin D disease
• alpha thalassemia-intellectual disability syndrome type 1
• hypertriglyceridemia 2
• cholesterol-ester transfer protein deficiency
• delta-beta-thalassemia
• hemoglobin E-beta-thalassemia syndrome
• dominant beta-thalassemia
• hemoglobin C-beta-thalassemia syndrome
• alpha-thalassemia-myelodysplastic syndrome
• Heinz body anemia
• glycogen storage disease VI
• cirrhosis, familial