DNAJC5 : DnaJ heat shock protein family (Hsp40) member C5
Description
The DNAJC5 (DnaJ heat shock protein family (Hsp40) member C5) is a protein-coding gene located on chromosome 20.
The DNAJC5 gene provides instructions for making a protein called cysteine string protein alpha (CSPα). This protein is found near nerve cells in the brain, where it plays a role in the transmission of nerve impulses. Specifically, CSPα is part of a group (complex) of proteins that is found on the membrane of sac-like structures called synaptic vesicles. Synaptic vesicles are found close to the ends of nerve cells and contain chemical messengers that transmit signals from one nerve cell to another. CSPα is involved in recycling proteins that are involved in nerve impulse transmission by re-folding misshapen proteins so that they can be used in additional transmissions.
DNAJC5 plays a role in regulated exocytosis, acting as a general chaperone and co-chaperone for the SNARE protein SNAP-25. It contributes to calcium-mediated control of a late stage in exocytosis. DNAJC5 is likely essential for presynaptic function and may be involved in calcium-dependent neurotransmitter release at nerve endings.
DNAJC5 is also known as CLN4, CLN4B, CSP, DNAJC5A, NCL, mir-941-2, mir-941-3, mir-941-4, mir-941-5.
