DNAJA3
Description
The DNAJA3 (DnaJ heat shock protein family (Hsp40) member A3) is a protein-coding gene located on chromosome 16.
DNAJA3, also known as Tumorous imaginal disc 1 (TID1), is a protein encoded by the DNAJA3 gene on chromosome 16. It belongs to the DNAJ/Hsp40 protein family and is involved in protein folding, degradation, and complex assembly by binding and activating Hsp70 chaperone proteins. As a mitochondrial protein, DNAJA3 maintains membrane potential and mitochondrial DNA (mtDNA) integrity, and participates in cellular processes like cell movement, growth, and death. It is associated with various diseases, including neurodegenerative diseases, inflammatory diseases, and cancers. DNAJA3 contains a conserved DnaJ domain with an HPD motif that interacts with Hsp70. This domain is composed of tetrahelical regions with a tripeptide of histidine, proline, and aspartic acid. Additionally, DNAJA3 features a glycine/phenylalanine (G/F) rich linker region and a central cysteine-rich region similar to a zinc finger repeat, characteristics of type I DnaJ molecular chaperones. Its N-terminal mitochondrial targeting sequence directs its localization to the mitochondrial matrix. DNAJA3 has two alternatively spliced forms: a long isoform of 43 kDa and a short isoform of 40 kDa. The long isoform has an additional 33 residues at its C-terminal, which is predicted to hinder its ability to regulate membrane potential.
DNAJA3 is also known as HCA57, TID1, Tid1-L, Tid1-S, hTID-1.
