DNAJA2

Description

The DNAJA2 (DnaJ heat shock protein family (Hsp40) member A2) is a protein-coding gene located on chromosome 16.

DNAJA2 is a human gene encoding a protein with structural features suggesting a role in multiprotein complexes. It shares similarity with yeast corepressors Hir1p and Hir2p involved in histone gene transcription. This protein interacts with other proteins, including HIRIPs, with HIRIP4 displaying high homology to human DNJ3/CPR3, mouse Dj3, and rat Dj2 gene products. The exact function of HIRIP4 remains unknown.

DNAJA2 acts as a co-chaperone for Hsc70, promoting ATP hydrolysis and assisting in the folding of unfolded proteins in conjunction with HSPA1A/B (in vitro).

DNAJA2 is also known as CPR3, DJ3, DJA2, DNAJ, DNJ3, HIRIP4, PRO3015, RDJ2.

Associated Diseases


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