DLX6-AS1
Description
The DLX6-AS1 (DLX6 antisense RNA 1) is a ncRNA gene located on chromosome 7.
DLX6-AS1 (also known as Evf-1) is a developmentally regulated long non-coding RNA. It is expressed in neurons in the subventricular zone of the developing forebrain in rats. Its expression is linked to that of the Shh (sonic hedgehog) and DLX families of genes, which are important in ventral forebrain and craniofacial development. An alternatively spliced form of DLX6-AS1, DLX6-AS2, forms a stable complex with the Dlx-2 protein. This complex activates transcription of Dlx-5 and Dlx-6. DLX6-AS2 regulates gene expression in a region of the brain that produces GABAergic interneurons during development. It is involved in the signaling pathway and works in conjunction with DLX homeodomain proteins to increase the effectiveness of the Dlx5/6 enhancer element within neural stem cells. The interneurons are found in the hippocampus of the adult brain, an area responsible for learning and memory. GABAergic interneurons have been implicated in a number of psychiatric disorders, including autism, schizophrenia, and epilepsy; as DLX6-AS2 controls the development of these neurons, it has been subject to studies regarding the causation of these disorders. DLX6-AS2 is the first known long non-coding RNA to be involved in organogenesis.
DLX6-AS1 is also known as DLX6-AS, DLX6AS, Evf-2, NCRNA00212.
