DLG2
Description
The DLG2 (discs large MAGUK scaffold protein 2) is a protein-coding gene located on chromosome 11.
DLG2, also known as Chapsyn-110 or PSD-93, is a protein encoded by the DLG2 gene in humans. As a member of the MAGUK family, it forms a heterodimer with a related family member, potentially interacting at postsynaptic sites to create a multimeric scaffold for clustering receptors, ion channels, and related signaling proteins. Various transcript variants have been identified, but their full-length nature remains to be fully determined. DLG2 has been shown to interact with GRIN2B and KCNJ12.
DLG2 plays a crucial role in the perception of chronic pain by modulating NMDA receptor signaling. It regulates the surface expression of NMDA receptors within the spinal cord's dorsal horn neurons. DLG2 interacts with the cytoplasmic tails of NMDA receptor subunits and inward rectifying potassium channels. Furthermore, it contributes to the regulation of synaptic stability at cholinergic synapses. DLG2 is part of the postsynaptic protein scaffold of excitatory synapses.
DLG2 is also known as PPP1R58, PSD-93, PSD93, chapsyn-110.
