DKK2
Description
The DKK2 (dickkopf WNT signaling pathway inhibitor 2) is a protein-coding gene located on chromosome 4.
DKK2, encoded by the DKK2 gene, is a member of the Dickkopf family of proteins. It is secreted and contains two cysteine-rich regions. DKK2 is involved in embryonic development by interacting with the Wnt signaling pathway. Depending on the cellular context and the presence of the co-factor Kremen 2, DKK2 can act as either an agonist or antagonist of Wnt/beta-catenin signaling. Its activity is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6).
DKK2 antagonizes the canonical Wnt signaling pathway by blocking the interaction between LRP5/6 and Wnt. It also forms a complex with the transmembrane protein KREMEN, leading to the internalization of LRP5/6. DKK2 is crucial during vertebrate development, inhibiting Wnt-regulated processes like axial patterning, limb formation, somitogenesis, and eye development. In adults, DKK2 is associated with bone formation and disease, cancer, and Alzheimer's disease.
DKK2 is also known as DKK-2.
Associated Diseases
- alopecia
- breast cancer
- X-linked endothelial corneal dystrophy
- granular corneal dystrophy type I
- lattice corneal dystrophy type I
- X-linked corneal dermoid
- autosomal dominant keratitis
