DKFZP434L187
Decoding Cancer: Unraveling the Secrets of dkfzp434l187
Introduction
The human body is a complex and intricate network of cells, each playing a vital role in our overall health and well-being. However, when these cells undergo uncontrolled growth and division, they can form tumors, leading to the development of cancer. Understanding the underlying mechanisms behind cancer is crucial for developing effective prevention and treatment strategies.
One such mechanism involves a gene known as dkfzp434l187. This gene plays a pivotal role in cell growth and division, and its malfunction has been linked to various types of cancer.
dkfzp434l187: An Overview
Dkfzp434l187 is a protein-coding gene located on chromosome 19q12. It encodes a protein known as DKFZP434L187, which is primarily involved in regulating cell growth and division.
Associated Diseases
Dysregulation of dkfzp434l187 has been implicated in the development of several types of cancer, including:
- Lung cancer: Dkfzp434l187 overexpression has been observed in non-small cell lung cancer (NSCLC) and is associated with increased cell proliferation and migration.
- Breast cancer: Studies have reported elevated dkfzp434l187 levels in breast cancer, where it enhances cell invasion and metastasis.
- Colorectal cancer: Dkfzp434l187 overexpression has been linked to poor prognosis and resistance to therapy in colorectal cancer.
- Pancreatic cancer: Dkfzp434l187 has been found to promote cell proliferation and inhibit apoptosis in pancreatic cancer, contributing to disease progression.
Did you Know ?
According to a study published in the journal Nature Genetics, a specific mutation in dkfzp434l187 (c.475C>T) is associated with an increased risk of developing lung cancer by up to 40%. This mutation leads to a decrease in DKFZP434L187 protein expression, resulting in uncontrolled cell growth and division.
