DIMT1
Description
The DIMT1 (DIM1 rRNA methyltransferase and ribosome maturation factor) is a protein-coding gene located on chromosome 5.
DIMT1 is an enzyme responsible for adding two methyl groups to adjacent adenosine bases within the loop of a specific hairpin structure located near the 3' end of the 18S ribosomal RNA (rRNA) molecule. This modification occurs within the 40S ribosomal subunit, a key component of the protein synthesis machinery. While DIMT1 possesses catalytic activity for modifying RNA, it also plays a crucial role in the processing of pre-rRNA into functional small-subunit rRNA, even in the absence of its RNA-modifying activity. This protein is part of the SSU processome, a large complex responsible for the initial assembly of the small eukaryotic ribosomal subunit. During this assembly process, DIMT1 collaborates with other ribosome biogenesis factors, an RNA chaperone, and ribosomal proteins. Together, they orchestrate a series of events including RNA folding, modification, rearrangement, cleavage, and targeted degradation of pre-ribosomal RNA by the RNA exosome.
DIMT1 is also known as DIM1, DIMT1L, HSA9761, HUSSY5.
