GCK : glucokinase

The GCK Gene: Unlocking the Sugar-Balancing Secrets

Description:

The GCK gene holds the blueprint for creating the glucokinase protein, a vital player in the body‘s sugar metabolism. Glucokinase is a gatekeeper in the sugar breakdown process, regulating the levels of glucose, the primary energy source for our cells.

Associated Diseases:

Mutations in the GCK gene can disrupt glucokinase function, leading to several health conditions:

• Maturity-Onset Diabetes of the Young (MODY): GCK gene defects can cause MODY, an inherited form of diabetes that typically affects children and young adults. MODY patients have impaired glucose tolerance, leading to elevated blood sugar levels and diabetes symptoms.

• Hyperinsulinemia: GCK mutations can also lead to hyperinsulinemia, a condition characterized by excessive insulin secretion. This can disrupt blood glucose regulation, contributing to weight gain and potential heart disease risk.

Did you Know ?

According to the Centers for Disease Control and Prevention (CDC), approximately 1 in 25,000 individuals worldwide is affected by MODY, making it a relatively rare but significant cause of diabetes in young people.