DHX29
Description
The DHX29 (DExH-box helicase 29) is a protein-coding gene located on chromosome 5.
DHX29 is a 155 kDa protein encoded by the DHX29 gene in humans. It belongs to the DEAH subfamily of RNA helicases, which are part of the DEAD box family. DHX29 is involved in translation initiation, specifically required for ribosomal scanning across stable mRNA secondary structures during initiation codon selection. It may also play a role in detecting viral nucleic acids in the cytoplasm. Reducing DHX29 levels leads to decreased protein translation and impaired proliferation in cancer cells. DHX29 interacts with the eukaryotic small ribosomal subunit (40S) and eIF3.
DHX29 is an ATP-binding RNA helicase involved in translation initiation. It is part of the 43S pre-initiation complex, which is essential for efficient translation initiation on mRNAs with structured 5'-UTRs in higher eukaryotes. DHX29 promotes the formation of the 48S complex by stimulating NTPase activity. It specifically binds to the 40S ribosome near the mRNA entry site. However, it does not exhibit processive helicase activity.
DHX29 is also known as DDX29.
Associated Diseases
- prostate cancer
- isolated spina bifida
- anencephaly 1
- spina bifida-hypospadias syndrome
- Dent disease
- medullary sponge kidney
- cancer
- tuberculosis
- Alzheimer disease
