DHRS4
Description
The DHRS4 (dehydrogenase/reductase 4) is a protein-coding gene located on chromosome 14.
DHRS4 (Dehydrogenase/reductase SDR family member 4) is an enzyme encoded by the DHRS4 gene in humans. It is a member of the short-chain dehydrogenase/reductase (SDR) family and functions as an NADPH-dependent oxidoreductase. DHRS4 plays a role in the metabolism of various compounds, including steroids, aldehydes, and xenobiotics.
DHRS4 is a NADPH-dependent oxidoreductase that catalyzes the reduction of various carbonyl-containing compounds, including ketosteroids, alpha-dicarbonyl compounds, aldehydes, aromatic ketones, and quinones. It specifically reduces 3-ketosteroids to 3beta-hydroxysteroids and benzil to R-benzoin, unlike non-primate DHRS4s which produce 3alpha-hydroxysteroids and S-benzoin. DHRS4 exhibits low activity towards all-trans-retinal and no activity towards 9-cis-retinal compared to non-primate mammals. Conversely, it can catalyze the NAD-dependent oxidation of 3beta-hydroxysteroids and alcohol, albeit with lower efficiency. DHRS4 plays a role in the metabolism of 3beta-hydroxysteroids, isatin, and xenobiotic carbonyl compounds.
DHRS4 is also known as CR, NRDR, PHCR, PSCD, SCAD-SRL, SDR-SRL, SDR25C1, SDR25C2.
Associated Diseases
- nonpapillary renal cell carcinoma
- cancer
- immune deficiency, familial variable
- hyper-IgM syndrome type 3
- hyper-IgM syndrome type 2
- immunodeficiency, common variable, 14
- hyper-IgM syndrome type 5
- graft versus host disease
