DHRS2

Description

The DHRS2 (dehydrogenase/reductase 2) is a protein-coding gene located on chromosome 14.

Dehydrogenase/reductase SDR family member 2 is an enzyme encoded by the DHRS2 gene in humans.

DHRS2 is a NADPH-dependent oxidoreductase that catalyzes the reduction of dicarbonyl compounds. It exhibits reductase activity in vitro with 3,4-hexanedione, 2,3-heptanedione, and 1-phenyl-1,2-propanedione as substrates. This enzyme might function as a dicarbonyl reductase in the enzymatic inactivation of reactive carbonyls, which are involved in covalent modification of cellular components. Additionally, it shows minor hydroxysteroid dehydrogenase activity toward bile acids such as ursodeoxycholic acid (UDCA) and isoursodeoxycholic acid (isoUDCA), suggesting a limited role in hormone regulation. DHRS2 lacks activity in vitro with retinoids and sugars as substrates. This protein attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21. It reduces proliferation, migration, and invasion of cancer cells, as well as the production of ROS in cancer.

DHRS2 is also known as HEP27, SDR25C1.

Associated Diseases

WES Whole Exome Sequencing

Clinical Exome Sequencing