DGKD
Description
The DGKD (diacylglycerol kinase delta) is a protein-coding gene located on chromosome 2.
Diacylglycerol kinase delta is an enzyme encoded by the DGKD gene in humans. This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid act as second messengers in signaling cascades. Their cellular concentrations are regulated by DGKD, suggesting its role in cellular signal transduction. Alternative splicing generates two transcript variants encoding different isoforms.
Diacylglycerol kinase delta (DGKD) converts diacylglycerol (DAG) into phosphatidic acid (PA), regulating the levels of these bioactive lipids. This enzyme acts as a central switch between signaling pathways activated by DAG and PA, which have different cellular targets and opposing effects in various biological processes. By controlling DAG levels, DGKD regulates PKC and EGF receptor signaling pathways and plays a crucial role in development. It may also regulate clathrin-dependent endocytosis.
DGKD is also known as DGK-delta, DGKdelta, dgkd-2.
