DGCR11
Description
The DGCR11 (DiGeorge syndrome critical region gene 11) is a ncRNA gene located on chromosome 22.
DGCR11 is a protein that is involved in the biogenesis of microRNAs (miRNAs). It is a component of the microprocessor complex, which is responsible for processing primary miRNA transcripts (pri-miRNAs) into precursor miRNAs (pre-miRNAs). DGCR11 specifically recognizes and binds to the stem-loop structure of pri-miRNAs, facilitating their cleavage by the RNase III enzyme Drosha. The resulting pre-miRNAs are then exported from the nucleus to the cytoplasm, where they undergo further processing to generate mature miRNAs.
DGCR11 plays a crucial role in the biogenesis of microRNAs (miRNAs), small non-coding RNAs that regulate gene expression. It acts as a key component of the microprocessor complex, a multi-protein assembly that processes primary miRNA transcripts (pri-miRNAs) into precursor miRNAs (pre-miRNAs). DGCR11 specifically recognizes and binds to the stem-loop structure of pri-miRNAs, facilitating their cleavage by the RNase III enzyme Drosha. The resulting pre-miRNAs are then exported from the nucleus to the cytoplasm, where they undergo further processing to generate mature miRNAs. DGCR11's involvement in miRNA biogenesis highlights its essential contribution to the intricate network of gene regulation mediated by miRNAs.
DGCR11 is also known as DGS-D.
