DGAT2
Description
The DGAT2 (diacylglycerol O-acyltransferase 2) is a protein-coding gene located on chromosome 11.
DGAT2 is an essential acyltransferase that catalyzes the final and irreversible step in the synthesis of triacylglycerol (TAG), utilizing diacylglycerol (DAG) and fatty acyl CoA as substrates. Its function is crucial for the synthesis and storage of intracellular triglycerides (PMID:27184406). DGAT2 likely plays a key role in lipid accumulation within the cell. In the liver, it is primarily responsible for incorporating newly synthesized fatty acids into triglycerides. In addition to its role in TAG synthesis, DGAT2 also functions as an acyl-CoA retinol acyltransferase (ARAT) (PMID:27184406). It can also utilize 1-monoalkylglycerol (1-MAkG) as an acyl acceptor to produce monoalkyl-monoacylglycerol (MAMAG) (PMID:28420705).
DGAT2 is also known as ARAT, GS1999FULL, HMFN1045.
