DERL2
Description
The DERL2 (derlin 2) is a protein-coding gene located on chromosome 17.
Derlin-2 is a protein that in humans is encoded by the DERL2 gene.
DERL2 is involved in the endoplasmic reticulum-associated degradation (ERAD) pathway for misfolded lumenal glycoproteins, but not for misfolded non-glycoproteins. It may form a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol, where they are ubiquitinated and degraded by the proteasome. DERL2 may also mediate the interaction between VCP and misfolded glycoproteins, and may be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation.
DERL2 is also known as CGI-101, DERtrin-2, F-LAN-1, F-LANa, FLANa, derlin-2.
