DEFB106A
Description
The DEFB106A (defensin beta 106A) is a protein-coding gene located on chromosome 8.
DEFB106A encodes Beta-defensin 106, a protein belonging to the defensin family, known for their microbicidal and cytotoxic properties. Defensins are short, processed peptides classified into three groups: alpha-defensins, beta-defensins, and theta-defensins. All beta-defensin genes are clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains two copies of the duplicated beta-defensin cluster, resulting in two identical copies of defensin, beta 106, named DEFB106A and DEFB106B, arranged in a head-to-head orientation. DEFB106A represents the more centromeric copy. Purified DEFB106A exhibits antimicrobial activity against Escherichia coli, Candida albicans, and Staphylococcus aureus.
DEFB106A exhibits antibacterial activity (PubMed:12600824) and acts as a ligand for the C-C chemokine receptor CCR2 (PubMed:23938203).
DEFB106A is also known as BD-6, DEFB-6, DEFB106.
