IL17C
Description
The IL17C (interleukin 17C) is a protein-coding gene located on chromosome 16.
IL-17C plays a key role in the innate immune response of epithelial tissues, particularly against intestinal bacteria. It acts in an autocrine manner, stimulating the production of antibacterial peptides and pro-inflammatory molecules to defend against pathogens. IL-17C signals through the NF-ΞΊB and MAPK pathways. It works synergistically with other cytokines like IL22, TNF, and IL1Ξ² to induce the expression of various antimicrobial peptides, including S100A8, S100A9, REG3A, REG3G, and DEFB2. The role of IL-17C can be both protective and pathogenic depending on the type of inflammation. It can maintain epithelial homeostasis after an inflammatory challenge or contribute to an inflammatory phenotype. Increased IL-17C/IL17RE signaling can also lead to an increased risk of autoimmune diseases.
IL17C is also known as CX2, IL-17C.
Associated Diseases
- major depressive disorder
- acne inversa, familial, 3
- X-linked intellectual disability-seizures-psoriasis syndrome
- hereditary palmoplantar keratoderma, Gamborg-Nielsen type
- acute kidney failure
- ichthyosis, lamellar, autosomal dominant
- common variable immunodeficiency
- immunodeficiency 51
- psoriasis 2
- inborn error of immunity
- intellectual disability, FRA12A type
