FRS2
Description
The FRS2 (fibroblast growth factor receptor substrate 2) is a protein-coding gene located on chromosome 12.
FRS2 is a protein encoded by the FRS2 gene in humans. This 80 kDa membrane-anchored signal transducing adaptor protein (STAP) links activated Receptor Tyrosine Kinases (RTKs) to multiple downstream signaling pathways, including MAPK/ERK, PI3K/AKT/mTOR, and PLCΞ³ pathways. It is overexpressed and amplified in several cancer types, including prostate cancer.
FRS2 acts as an adaptor protein, linking activated FGR and NGF receptors to downstream signaling pathways. It plays a crucial role in activating MAP kinases and phosphorylating PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to FGFR1 activation. FRS2 also modulates signaling through SHC1 by competing for a binding site on NTRK1.
FRS2 is also known as FRS1A, FRS2A, FRS2alpha, SNT, SNT-1, SNT1.
