DNAJC5 : DnaJ heat shock protein family (Hsp40) member C5
Description
The DNAJC5 (DnaJ heat shock protein family (Hsp40) member C5) is a protein-coding gene located on chromosome 20.
The DNAJC5 gene provides instructions for making a protein called cysteine string protein alpha (CSPΞ±). This protein is found near nerve cells in the brain, where it plays a role in the transmission of nerve impulses. Specifically, CSPΞ± is part of a group (complex) of proteins that is found on the membrane of sac-like structures called synaptic vesicles. Synaptic vesicles are found close to the ends of nerve cells and contain chemical messengers that transmit signals from one nerve cell to another. CSPΞ± is involved in recycling proteins that are involved in nerve impulse transmission by re-folding misshapen proteins so that they can be used in additional transmissions.
DNAJC5 plays a role in regulated exocytosis, acting as a general chaperone and co-chaperone for the SNARE protein SNAP-25. It contributes to calcium-mediated control of a late stage in exocytosis. DNAJC5 is likely essential for presynaptic function and may be involved in calcium-dependent neurotransmitter release at nerve endings.
DNAJC5 is also known as CLN4, CLN4B, CSP, DNAJC5A, NCL, mir-941-2, mir-941-3, mir-941-4, mir-941-5.
