DDX19B
Description
The DDX19B (DEAD-box helicase 19B) is a protein-coding gene located on chromosome 16.
DDX19B is an ATP-dependent RNA helicase encoded by the DDX19B gene in humans. DEAD box proteins, characterized by the conserved DEAD motif, are implicated in various cellular processes involving RNA secondary structure modification, including translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. DDX19B, a member of this family, exhibits RNA-dependent ATPase and ATP-dependent RNA-unwinding activities. It is localized to the cytoplasmic fibrils of the nuclear pore complex, where it participates in the export of mRNA from the nucleus. Multiple isoforms of DDX19B are generated through alternative splicing.
DDX19B is an ATP-dependent RNA helicase involved in mRNA export from the nucleus. It functions as a remodeler of ribonucleoprotein particles, replacing proteins bound to nuclear mRNA with cytoplasmic mRNA binding proteins during mRNA export.
DDX19B is also known as DBP5, DDX19, RNAh.
Associated Diseases
- male infertility with teratozoospermia due to single gene mutation
- partial chromosome Y deletion
- congenital bilateral absence of vas deferens
- spermatogenic failure 61
- spermatogenic failure 73
- spermatogenic failure 74
- spermatogenic failures 50
- spermatogenic failure 26
- spermatogenic failure 31
- spermatogenic failure 52
- spermatogenic failure 23
- spermatogenic failure 63
- spermatogenic failure 25
