DDIT4L
Description
The DDIT4L (DNA damage inducible transcript 4 like) is a protein-coding gene located on chromosome 4.
DDIT4L (also known as REDD2) is a protein encoded by the DDIT4L gene, located on chromosome 4 in humans. It acts as a negative regulator of mTOR, a key protein involved in cell growth and survival. DDIT4L is a stress-responsive protein, its expression increases under hypoxic conditions, and it can promote cell death through the regulation of mTOR activity and reduction of thioredoxin-1. In cardiomyocytes, increased expression of DDIT4L under pathological stress promotes autophagy by inhibiting mTORC1, not mTORC2. DDIT4L has also been implicated in fibrosis, where its expression is repressed by the lncRNA H19X, leading to increased collagen expression and fibrosis. In cardiac hypertrophy, DDIT4L expression is increased in pathological but not physiological cases, contributing to mild systolic dysfunction, increased baseline autophagy, reduced mTORC1 activity, and increased mTORC2 activity.
DDIT4L is also known as REDD2, Rtp801L.
