DCP1A
Description
The DCP1A (decapping mRNA 1A) is a protein-coding gene located on chromosome 3.
DCP1A (mRNA-decapping enzyme 1A) is a protein involved in mRNA degradation. It functions as a decapping enzyme, removing the 5' cap from mRNA molecules, a critical step in both general and regulated mRNA decay. DCP1A forms a complex with another decapping enzyme, DCP2, and this complex interacts with the nonsense-mediated decay factor hUpf1. This interaction suggests a role for DCP1A in the degradation of mRNAs containing premature termination codons. Additionally, DCP1A is involved in the TGF-beta signaling pathway. DCP1A has been shown to interact with various proteins, including DCP2, UPF1, EDC3, DDX6, EDC4/HEDLS, XRN1, LSM1, DCP1B, DDX17, PNRC2, SMAD4, ZC3HAV1, ZFP36L1, NBDY, and DHX34. In plants, the Arabidopsis thaliana homolog of DCP1A interacts with the type XI myosin motor protein.
DCP1A is essential for mRNA degradation, both in normal mRNA turnover and in nonsense-mediated mRNA decay. It removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. DCP1A contributes to the transactivation of target genes after stimulation by TGFB1. It is essential for embryonic development.
DCP1A is also known as HSA275986, Nbla00360, SMAD4IP1, SMIF.
