DBI

Description

The DBI (diazepam binding inhibitor, acyl-CoA binding protein) is a protein-coding gene located on chromosome 2.

DBI can refer to Diazepam-binding inhibitor, a human gene.

DBI binds to medium and long-chain acyl-CoA esters with high affinity and may act as an intracellular carrier of these esters. It can also displace diazepam from the benzodiazepine (BZD) recognition site on the GABA type A receptor, suggesting a possible role as a neuropeptide that modulates GABA receptor activity.

DBI is also known as ACBD1, ACBP, CCK-RP, EP.

Associated Diseases

• glycogen storage disease VI
• progressive familial intrahepatic cholestasis
• glycine N-methyltransferase deficiency
• Crigler-Najjar syndrome type 2
• neonatal intrahepatic cholestasis due to citrin deficiency
• intrahepatic cholestasis
• transient infantile hypertriglyceridemia and hepatosteatosis
• infantile hypertrophic cardiomyopathy due to MRPL44 deficiency
• bile acid conjugation defect 1
• combined low LDL and fibrinogen
• cholesterol-ester transfer protein deficiency
• TMEM199-CDG