DBI
Description
The DBI (diazepam binding inhibitor, acyl-CoA binding protein) is a protein-coding gene located on chromosome 2.
DBI can refer to Diazepam-binding inhibitor, a human gene.
DBI binds to medium and long-chain acyl-CoA esters with high affinity and may act as an intracellular carrier of these esters. It can also displace diazepam from the benzodiazepine (BZD) recognition site on the GABA type A receptor, suggesting a possible role as a neuropeptide that modulates GABA receptor activity.
DBI is also known as ACBD1, ACBP, CCK-RP, EP.
Associated Diseases
- glycogen storage disease VI
- progressive familial intrahepatic cholestasis
- glycine N-methyltransferase deficiency
- Crigler-Najjar syndrome type 2
- neonatal intrahepatic cholestasis due to citrin deficiency
- intrahepatic cholestasis
- transient infantile hypertriglyceridemia and hepatosteatosis
- infantile hypertrophic cardiomyopathy due to MRPL44 deficiency
- bile acid conjugation defect 1
- combined low LDL and fibrinogen
- cholesterol-ester transfer protein deficiency
- TMEM199-CDG
