DAPP1
Description
The DAPP1 (dual adaptor of phosphotyrosine and 3-phosphoinositides 1) is a protein-coding gene located on chromosome 4.
DAPP1 is a protein encoded by the DAPP1 gene in humans. It functions as a dual adapter for phosphotyrosine and 3-phosphoinositide.
DAPP1 acts as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR) signaling downstream of PI3K.
DAPP1 is also known as BAM32.
Associated Diseases
- endometrial cancer
- isolated agammaglobulinemia
- immune deficiency, familial variable
- hyper-IgM syndrome type 2
- common variable immunodeficiency
