DAOA
Description
The DAOA (D-amino acid oxidase activator) is a protein-coding gene located on chromosome 13.
DAOA (D-amino acid oxidase activator, also known as G72) is a protein enriched in various parts of the brain, spinal cord, and testis. DAOA is thought to interact with D-amino acid oxidase, a peroxisomal enzyme, and its gene was associated with schizophrenia in a number of studies. In separate studies, it has been shown to confer susceptibility to bipolar disorder. Therefore, it has been important in researching whether the Kraepelinian dichotomy is genuine. The gene itself was discovered during an investigation of chromosomal 13q22-q34 region, which was previously linked to schizophrenia. G72 is transcribed into several proteins due to alternative splicing; the longest protein is called LG72 and consists of 153 amino acids. Although the protein was initially found to interact with DAO in a yeast 2-hybrid experiment, one recent in vivo experiment showed LG72 presence only in mitochondria and failed to confirm the interaction.
DAOA (D-amino acid oxidase activator) may suppress the activity of DAO (D-amino acid oxidase) and SOD1 (superoxide dismutase 1) and promote their degradation. Conversely, DAOA has also been suggested to function as a DAO activator. DAOA may stimulate the degradation of DDO (D-aspartate oxidase) and play a role in mitochondrial fission. DAOA interacts directly with DAO, SOD1, DDO, and MSRB2.
DAOA is also known as LG72, SG72.
