DAGLA
Description
The DAGLA (diacylglycerol lipase alpha) is a protein-coding gene located on chromosome 11.
DAGLA is a serine hydrolase that plays a crucial role in the production of the endocannabinoid 2-arachidonoylglycerol (2-AG). It specifically hydrolyzes diacylglycerols (DAGs) containing arachidonic acid (AA) at the sn-2 position, releasing 2-AG. DAGLA exhibits minimal activity against other lipids like monoacylglycerols and phospholipids. This enzyme is essential for regulating 2-AG signaling in the central nervous system (CNS), influencing retrograde suppression at synapses, axonal growth during development and neurogenesis, and the physiological regulation of anxiety and depressive behaviors. Additionally, DAGLA participates in neuroinflammatory responses in the brain, particularly in response to LPS-induced microglial activation.
DAGLA is also known as C11orf11, DAGL(ALPHA), DAGLALPHA, NOC2, NSDDR.
Associated Diseases
- spinocerebellar ataxia type 20
- autosomal dominant cerebellar ataxia
- thyroid gland adenocarcinoma
- major depressive disorder
- refractive error
