DAD1
Description
The DAD1 (defender against cell death 1) is a protein-coding gene located on chromosome 14.
DAD1, the defender against apoptotic cell death, is an enzyme encoded by the DAD1 gene in humans. Initially identified as a negative regulator of programmed cell death, DAD1's loss was found to trigger apoptosis. DAD1 is believed to be an integral subunit of oligosaccharyltransferase, both in the intact membrane and in its purified form. This highlights the importance of N-linked glycosylation in eukaryotic cells. DAD1 has been shown to interact with MCL1.
DAD1 is a subunit of the oligosaccharyl transferase (OST) complex, which catalyzes the initial step in protein N-glycosylation. This process involves transferring a specific glycan from a lipid carrier to an asparagine residue in a nascent polypeptide chain. N-glycosylation occurs during protein synthesis, and the OST complex associates with the Sec61 complex, which mediates protein translocation across the endoplasmic reticulum. All subunits of the OST complex are crucial for its optimal activity. DAD1 is required for the assembly of both SST3A- and SS3B-containing OST complexes. Loss of DAD1 triggers apoptosis.
DAD1 is also known as OST2.
Associated Diseases
- COVID-19
- narcolepsy-cataplexy syndrome
- syndactyly type 4
- syndactyly type 1
- syndactyly type 5
- mesoaxial synostotic syndactyly with phalangeal reduction
- syndactyly type 3
- brachydactyly-syndactyly syndrome
- brachydactyly type A2
- synpolydactyly type 1
- split-foot malformation-mesoaxial polydactyly syndrome
- brachydactyly type A7
- polydactyly of a triphalangeal thumb
- brachydactyly type B2
- polysyndactyly 4
