CYP4B1
CYP4B1: A Versatile Enzyme with Diverse Roles in Health and Disease
Description:
CYP4B1 belongs to the cytochrome P450 (CYP) enzyme superfamily, a group of proteins responsible for metabolizing a wide range of compounds in the body. CYP4B1 is primarily found in the liver, but it is also present in other tissues, including the lungs, kidneys, and brain. This enzyme plays a crucial role in the metabolism of various substances, including drugs, lipids, steroids, and fatty acids.
Associated Diseases:
CYP4B1 has been linked to several diseases, including:
- Lung cancer: CYP4B1 is involved in the metabolism of tobacco carcinogens, and its overexpression has been associated with an increased risk of developing lung cancer.
- Atopic dermatitis: CYP4B1 metabolizes arachidonic acid, which is involved in the inflammatory response. Dysregulation of CYP4B1 activity has been linked to atopic dermatitis, an inflammatory skin condition.
- Diabetes: CYP4B1 plays a role in the metabolism of lipids and glucose. Alterations in CYP4B1 expression have been implicated in the development of type 2 diabetes.
Did you Know ?
CYP4B1 is one of the most polymorphic CYPs in the human genome, with over 100 different genetic variants identified. These genetic variations can significantly impact CYP4B1 activity and drug metabolism, contributing to inter-individual differences in drug response and toxicity.
