CYP2C18
Description
The CYP2C18 (cytochrome P450 family 2 subfamily C member 18) is a protein-coding gene located on chromosome 10.
CYP2C18 is a protein encoded by the CYP2C18 gene in humans. It belongs to the cytochrome P450 superfamily of enzymes, which are monooxygenases that catalyze various reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids. While its specific substrate is yet to be determined, CYP2C18 localizes to the endoplasmic reticulum. The CYP2C18 gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. CYP2C18 also possesses epoxygenase activity, attacking various long-chain polyunsaturated fatty acids at their double bonds to form epoxide products that act as signaling agents. It metabolizes arachidonic acid to epoxyeicosatrienoic acids (EETs), linoleic acid to 9,10-epoxy octadecenoic acids (vernolic acid, linoleic acid 9:10-oxide, or leukotoxin) and 12,13-epoxy-octadecenoic acids (coronaric acid, linoleic acid 12,13-oxide, or isoleukotoxin), docosahexaenoic acid to epoxydocosapentaenoic acids (EDPs), and eicosapentaenoic acid to epoxyeicosatetraenoic acids (EEQs). While CYP2C19, CYP2C8, CYP2C9, CYP2J2, and possibly CYP2S1 are the main producers of these metabolites, CYP2C18 may contribute to their production in certain tissues.
CYP2C18 is also known as CPCI, CYP2C, CYP2C17, P450-6B/29C, P450IIC17.
