CYP2A13
CYP2A13: A Crucial Player in Drug Metabolism
Description
CYP2A13, short for cytochrome P450 2A13, is a crucial liver enzyme involved in metabolizing a wide range of drugs, toxins, and other chemicals. This enzyme plays a significant role in the body's detoxification process, helping to eliminate harmful substances.
CYP2A13 is expressed in various tissues, including the liver, lungs, and intestines. It belongs to the cytochrome P450 superfamily, known for its ability to catalyze oxidative reactions in the body. The enzyme primarily metabolizes nicotine, the addictive substance found in tobacco products, along with several other drugs and chemicals.
Associated Diseases
Dysregulation or variations in CYP2A13 activity have been linked to several diseases, including:
- Lung Cancer: CYP2A13 activation by cigarette smoke can lead to the formation of harmful carcinogens, increasing the risk of lung cancer.
- Idiopathic Pulmonary Fibrosis (IPF): Alterations in CYP2A13 expression have been associated with the development and progression of IPF, a chronic lung condition.
- Tobacco Addiction: CYP2A13 plays a role in nicotine metabolism and addiction. Variations in the enzyme's activity can influence the severity of nicotine dependence.
Did you Know ?
Cigarette smoking is one of the most significant factors influencing CYP2A13 activity. Studies have shown that smokers have significantly higher levels of CYP2A13 expression than non-smokers. This increased enzyme activity can enhance nicotine metabolism, contributing to addiction and the adverse health effects associated with smoking.
