CXCR5
Description
The CXCR5 (C-X-C motif chemokine receptor 5) is a protein-coding gene located on chromosome 11.
CXCR5, also known as CD185 or Burkitt lymphoma receptor 1 (BLR1), is a G protein-coupled receptor that binds to the chemokine CXCL13 (also known as BLC). It plays a critical role in guiding T cells and B cells to specific locations within the lymphatic system. CXCR5 is expressed on both CD4 and CD8 T cells, but it is particularly important for T follicular helper (Tfh) cells, which are essential for antibody production. CXCR5 is expressed in Burkitt's lymphoma and lymphatic tissues, including follicles in lymph nodes and the spleen. It facilitates B cell migration to the lymph nodes by responding to CXCL13 secretions. Some studies suggest that CXCR5, through its interaction with CXCL13, contributes to the development of lymph nodes and Peyer's patches by recruiting hematopoietic precursor cells. CXCR5 is essential for T cells to access B cell follicles, which is crucial for the production of high-affinity antibodies, as B cells and T cells need to interact to activate the Ig class switch.
CXCR5 is also known as BLR1, CD185, MDR15.
