CXCR1
Description
The CXCR1 (C-X-C motif chemokine receptor 1) is a protein-coding gene located on chromosome 2.
CXCR1 (C-X-C motif chemokine receptor 1) is a chemokine receptor, formerly known as IL8RA (interleukin 8 receptor, alpha). It is a member of the G-protein-coupled receptor family and binds to IL-8 with high affinity, triggering downstream signaling through a G-protein-activated second messenger system. CXCR1 is crucial for neutrophil chemotaxis and activation. Studies in mice indicate that CXCR1 plays a role in inhibiting embryonic oligodendrocyte precursor migration in the developing spinal cord. CXCR1 is located in a gene cluster on chromosome 2q33-q36, alongside IL8RB, another high affinity IL8 receptor, and IL8RBP, a pseudogene of IL8RB.
CXCR1 is also known as C-C, C-C-CKR-1, CD128, CD181, CDw128a, CKR-1, CMKAR1, IL8R1, IL8RA, IL8RBA.
