CXCL9
Description
The CXCL9 (C-X-C motif chemokine ligand 9) is a protein-coding gene located on chromosome 4.
CXCL9, or Chemokine (C-X-C motif) ligand 9, is a small cytokine belonging to the CXC chemokine family. It's also known as Monokine induced by gamma interferon (MIG). CXCL9 plays a role in chemotaxis, the differentiation and multiplication of leukocytes, and tissue extravasation. The CXCL9/CXCR3 receptor system regulates immune cell migration, differentiation, and activation. This regulation involves attracting immune cells like cytotoxic lymphocytes (CTLs), natural killer (NK) cells, NKT cells, and macrophages, as well as activating them through Th1 polarization in response to IFN-γ. Tumor-infiltrating lymphocytes, which are crucial for clinical outcomes and predicting responses to checkpoint inhibitors, are affected by this axis. While in vivo studies indicate the axis promotes tumorigenesis by increasing tumor proliferation and metastasis, CXCL9 primarily drives lymphocytic infiltration to target areas and suppresses tumor growth. CXCL9 is closely linked to CXCL10 and CXCL11, other CXC chemokines located near the CXCL9 gene on chromosome 4. All three chemokines interact with the CXCR3 receptor to exert their chemotactic effects.
CXCL9 is also known as CMK, Humig, MIG, SCYB9, crg-10.
